|Place of Origin:||China|
|Minimum Order Quantity:||10 Grams|
|मूल्य:||1.5 usd dollars per gram|
|Packaging Details:||Discreet and safe foil bag|
|Delivery Time:||Within 12hours after payment|
|Payment Terms:||West Union, T/T, Money Gram.,Bitcorn and bank transfer, D/P|
|Supply Ability:||10000 Kg|
|Molecular Formula:||C18H14F4N2O4S||Description:||White powder|
|Applications:||Pharmaceutical raw materials||Function:||Hormone-refractory prostate cancer|
CAS 90357-06-5 Prostate Cancer Treatment Steroids USP 36 Bicalutamide - Casodex
Application:With luteinising-hormone-releasing hormone (LHRH) analogues or surgical orchiectomy combined applied in the treatment of advanced prostate cancer.
|Use||Objective To evaluate the efficacy of bicalutamid ( casodex) in the treatment of hormone-refractory prostate cancer|
1kg/Aluminum foil bag
1kg/ Aluminium Tin
25kg/ Aluminum Drum
Delivery Time:Usually within 2 working days after confirming the payment.
Shipping details: DHL; TNT; UPS or EMS
Bicalutamid has a molecular weight of 430.37. The pKa' is approximately 12. Bicalutamid is a fine white to off white powder which is practically insoluble in water at 37°C (5 mg per 1000 mL), slightly soluble in chloroform and absolute ethanol, sparingly soluble in methanol, and soluble in acetone and tetrahydrofuran.CASODEX (bicalutamid) is a racemate with its antiandrogenic activity being almost exclusively exhibited by the R-enantiomer of bicalutamid; the S-enantiomer is essentially inactive.
Bicalutamid is used primarily in the treatment of early and advanced prostate cancer. It is approved at a dosage of 50 mg/day as a combination therapy with a gonadotropin-releasing hormone (GnRH) analogue or orchiectomy (that is, surgical or medical castration) in the treatment of stage D2 metastatic prostate cancer (mPC), and as a monotherapy at a dosage of 150 mg/day for the treatment of stage C or D1 locally advanced prostate cancer (LAPC). Although effective in mPC and LAPC, bicalutamid is no longer indicated for the treatment of localized prostate cancer (LPC) due to negative findings in the Early Prostate Cancer (EPC) trial.
Read the Patient Information Leaflet if available from your pharmacist before you start taking bicalutamid and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Bicalutamid is used to treat prostate cancer that has spread to other areas of the body. It is used in combination with hormone treatment. This medication works by blocking the action of male hormones in the prostate, slowing growth of the tumors.
|Appearance||White or off-white crystalline powder||Conform|
|Residue on ignition||≤0.10%||0.08%|
|Particle size||90%<10um, 50%<5um||Conform|
|Related substances||Des-fluoro analog1≤0.2%||Negative|
|Des hydroxyl analog3≤0.2%||Negative|
|Individual unspecified impurity≤0.1%||0.09%|
|Total unspecified impurities≤0.3%||0.27%|
|Assay||98.0%~102.0%(on dried basis)||99.8%|
|Residual solvents||Meet the requirements of ICH Q3C||Conform|
6. Side effects
The side effect profile of bicalutamid is highly sex-dependent. In women, the side effects of pure antiandrogens/NSAAs are minimal, and bicalutamid has been found to be very well-tolerated.
In men however, due to androgen deprivation, a variety of side effects of varying severity may occur during bicalutamid treatment, with breast pain/tenderness and gynecomastia being the most commonand others including physical feminization and demasculinization in general (e.g., reduced body hair growth/density, decreased muscle mass and strength, changes
in fat mass and distribution, and reduced penile length), hot flashes, sexual dysfunction (including loss of libido and erectile dysfunction), depression, fatigue, weakness, anemia, and decreased
semen/ejaculate volume.General side effects of bicalutamid that may occur in either sex may include diarrhea, constipation, abdominal pain, nausea, dry skin, itching, and rash.The drug is well-tolerated at higher dosages (than the 50 mg/day dosage), with rare additional side effects
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